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In addition, indirect comparisons also result in less precise estimates of treatment effects compared with the same number of similarly sized head-to-head trials because methods for indirect analyses incorporate additional uncertainty from combining 22, 23 different sets of trials. Because of this, we pursued an exploratory analysis combining the indirect and direct pooled estimates using a Bayesian approach. Data from indirect comparisons was synthesized with data from direct, head-to-head studies when possible. Using a Bayesian data analytical framework, effect size estimated from the indirect analysis was used as the prior probability distribution in a meta-analysis of the data from the direct head-to-head studies. Peer Review and Public Comment We requested and received peer review of the Sildigra low price from 2 Sildigra low price and Sildigra low price experts.
Their Sildigra low prices were reviewed and, where possible, incorporated into the final document. We received comments from 6 pharmaceutical companies. For Update 1, we received dossiers from 5 pharmaceutical manufacturers: By applying the eligibility and exclusion criteria to titles and Sildigra low prices of all identified citations, we obtained full-text copies of 480 citations. After re-applying the criteria for inclusion, we ultimately included 166 publications, comprising 43 for Update 1.
See Appendix D for a list of excluded studies and reasons for exclusion at this stage.
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